专业人员如何Genetic Matching – find a genetically compatible donor

    Genetic Matching – find a genetically compatible donor

    All sperm donors at Cryos have been thoroughly screened to minimize the risk of a child inheriting a genetic disease. But the recipient’s genes - and the genetic compatibility - of course play a part too. With our Genetic Matching services, you and your patients can find out whether a donor’s genes match your patient’s.


    At Cryos, we want to help you give your patients the best possible chances for having a healthy child. By thoroughly testing and screening all donor candidates, we put a lot of resources into minimizing the risk related to the use of donor sperm. But the risk of a child inheriting a genetic disease is not isolated to the donor. By also comparing the genes of your patient and the chosen donor, your patient will get even more assurance regarding the genes that are passed on to the child. That is why we offer Genetic Matching.

    Patient ready for fertility treatment with Cryos donor after Genetic Matching

    What is Genetic Matching?

    Genetic Matching is an optional add-on when choosing a donor at Cryos. By using our Genetic Matching services, you can find out whether the genes of your patient and a particular donor are a good match before performing fertility treatment. If the test shows that they are not a good match and that your patient will face an increased risk of passing on diseases to children if she proceeds with the chosen donor, she can, free of charge, choose a new donor to match her genes up against.

    To avoid that the chosen donor is sold out while waiting for the Genetic Matching result, we highly recommend that you place an order of at least 3 sperm straws at the same time as ordering Genetic Matching. Just make sure to choose the latest possible shipping date, so your order will not be shipped before you have the test result. You will get the result within 6 weeks, and if it is a no-match, you can terminate your order and get a refund.

    Below you can learn more about why and how to order Genetic Matching.

    Different Genetic Matching services – incl. match guarantee

    At Cryos, we offer different Genetic Matching services depending on your patient’s situation and needs.

    Single Gene Matching – Get to know if the donor carries a variant in the same gene as your patient

    The Single Gene Matching solution is for people who already know that they are a carrier of a recessive genetic disease and want to be sure that the donor they choose is not a carrier of a mutation in the same gene.

    To perform this type of matching, we need you to provide documentation of your patient’s carrier status and let us know which gene(s) to look at. With Single Gene Matching, we offer to test up to 3 genes.

    If your patient is a known carrier of a recessive genetic disease, we highly recommend that you inform her about the possibility of Single Gene Matching.

    Panel Matching – Broad matching of more than 300 genes

    The Panel Matching solution is for people who would like to get a broad and general matching for genetic diseases with recessive inheritance. With Genetic Panel Matching, we will match more than 300 of your patient’s recessive genes up against the genes of the chosen donor.

    To do this, all we need is a saliva sample that your patient can make at home. We will send your patient a test kit by mail once we have received the payment. 

    Saliva kit for genetic testing before use of donor sperm

    What are the costs of Genetic Matching?

    Genetic Matching is an optional add-on when ordering donor sperm. The price of this service depends on which type of Genetic Matching you choose. You can see our donor sperm prices here. Besides the added costs, all that is required is either a saliva sample from your patient or documentation of your patient’s known carrier status, depending on which service you choose.

    What does the Genetic Matching result mean?

    No matter which of our Genetic Matching services you choose, the result will either be ‘a match’ or ‘a no-match’.

    If the donor is a no-match

    If the chosen donor turns out to be a ‘no-match,’ you can, free of charge, choose a new donor to match your patient’s genes up against.

    If the donor is a match

    If you receive a match, it means that your patient and the donor do not carry any of the same variants within the tested genes and that you can go ahead and perform the treatment using this donor’s sperm. If you reserved straws while ordering Genetic Matching, you can log in to your Cryos account and request delivery.

    How to order Genetic Matching of a Cryos donor

    1. Search for a donor available for Genetic Matching (you can add Genetic Matching as a filter)
    2. Once you have chosen a donor, go to his donor profile online and add the number of sperm straws you want to order in your basket (we recommend ordering at least 3 straws)
    3. Then choose which of our Genetic Matching services you want (Single Gene or Panel Matching) and add to basket
    4. Continue to checkout and fill out the required information about the genetic parent (if Single Gene Matching: Upload documentation of your patient’s known carrier status)
    5. Make sure not to request delivery until the match result comes in (this can take up to 6 weeks)
    6. Finalize your order
    7. Only for Panel Matching: Once we receive the payment, we will send your patient a test kit and instructions by mail so she can make a saliva sample. When the sample is done, it must be sent to our cooperating partners, using the accompanying packaging and shipping label, or to Cryos who will then forward it.

    Within approximately 6 weeks, our Clinic Account Team will contact you with the result to let you know whether the donor is a match or not. You will also receive documentation of the test result via email. 

     

     

    Why do genetic testing before a pregnancy?

    Even though we feel healthy and well, the fact is that all human beings are carriers of an unknown number of recessive gene variants (mutations) that might be passed on to our children. Most people do not know what they are carriers of and will never be affected by it.

    A child conceived with donor sperm will inherit half of its genes from the sperm donor and half of its genes from the genetic mother. If both parts carry a variation in the same gene, there is an increased risk of the child developing a disease. This risk is the same for all children, donor-conceived or not.

    At Cryos, we perform an extensive screening of all donor candidates in which we assess his general condition as well as the medical and genetic history of both him and his family members in three generations. We also perform a genetic carrier test, looking for the most common genetic variants causing:

    • Cystic fibrosis
    • Hemoglobinopathies (including Alfa thalassemia, Beta thalassemia, and Sickle cell)
    • Spinal muscular atrophy
    • Tay Sachs
    • Non-syndromic deafness (GJB2)

    as these are among the most frequent hereditary diseases.

    However, the donor screening does not take the recipient’s genes into account. In other words, despite our thorough screening, there is still a small risk of a child inheriting a disease, and this risk will be higher if both the sperm donor and the genetic mother carry a variation in the same gene.

    If you or your patient want to know the risk and be able to act on it before the fertility treatment, Genetic Matching is a good opportunity. With this test, we will match your patient’s genes up against the donor’s and assess whether they are genetically compatible.

    In the video below, you can learn more about Genetic Matching.

    Can genetic testing completely prevent diseases in children?

    Even though we conduct a matching between your patient and a donor and look for recessive diseases, we cannot eliminate the risk of the child developing a genetic disease. There will always be a small residual risk, as not all genes will be examined, and new or unknown mutations cannot always be identified using matching either.

    Do you have questions regarding Genetic Matching?

    Our Clinic Account Team will be happy to answer any questions you might have and assist you in ordering Genetic Matching of one or more donors.

    Contact Cryos